Category Archives: book club
I have decided that, from time to time, I will post some book recommendation here on this blog. This is the first of this series, dedicated to a pair of books on the evolution of the human genome and the … Continue reading
The fifth chapter of prof A . Wagner’s “Origins of Evolutionary Innovations” tries to answer to the question: “Under which common principles do metabolic networks, regulatory circuits, and sequence folds evolve?“. It also formalizes a framework for a theory of … Continue reading
The 4th chapter of “Origins of Evolutionary Innovations” discusses variation in protein and RNA sequences. How much aminoacids or nucleotides can I change in a sequence, without breaking its fold? How new fold and functions are found in evolution? Wagner … Continue reading
Today, in the metro, I have finally understood what is the form of a genotype space. A genotype space is a representation of all the possible genotypes that can possibly exist, and in which two neighbor points are different only … Continue reading
Here is the third chapter of “Origins of Evolutionary Innovations”! This chapter describes innovations in regulatory systems, and the evolution of networks of transcription factor sites. The most important message of this chapter is that regulatory circuits can suffer a … Continue reading
In the second chapter, Wagner discusses the variability of metabolic networks. How do metabolic networks evolve? How many reactions can I remove or add to a metabolic network, without altering its phenotype? How much the phenotype of a metabolic network … Continue reading
We just finished the first session of the book “Origins of Evolutionary Innovations” by A. Wagner, on Chapter 1. Click on “Continue Reading” to see a resume of this chapter.