Phylo is a game where players are required to manually edit a multiple alignment. The player who can make the best multiple alignment, maximizing the matches and reducing gaps, gets the best score.
This is a very funny and innovative idea. It is based on the principle that humans are better at identifying patterns than computers, and that the problem of calculating a multiple alignment is so complex that even the most advanced multiple alignment software does not find the best solution for a large set of sequences, and that a manual editing of a multiple alignment is always required.
You may have already heard about fold.it, a similar game based on protein folding: this is the answer for the guys who work in the field of multiple alignments and phylogeny. I am happy because I belong to this second group :-).
(source: http://oggiscienza.wordpress.com/2010/12/09/farmville-fatti-da-parte)